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Strategies for Optimizing the Serum Persistence of Engineered Human Arginase I for Cancer Therapy

Systemic l-Arginine depletion following intravenous administration of l-Arginine hydrolyzing enzymes has been shown to selectively impact tumors displaying urea-cycle defects including a large fraction of hepatocellular carcinomas, metastatic melanomas and small cell lung carcinomas. However, the hu...

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Detalhes bibliográficos
Main Authors: Stone, Everett, Chantranupong, Lynne, Gonzalez, Candice, O'Neal, Jamye, Rani, Mridula, VanDenBerg, Carla, Georgiou, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294146/
https://ncbi.nlm.nih.gov/pubmed/22001609
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.09.097
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