Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency

Arginase deficiency is caused by deficiency of arginase 1 (ARG1), a urea cycle enzyme that converts arginine to ornithine. Clinical features of arginase deficiency include elevated plasma arginine levels, spastic diplegia, intellectual disability, seizures and growth deficiency. Unlike other urea cy...

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Veröffentlicht in:Hum Mol Genet
Hauptverfasser: Burrage, Lindsay C., Sun, Qin, Elsea, Sarah H., Jiang, Ming-Ming, Nagamani, Sandesh C.S., Frankel, Arthur E., Stone, Everett, Alters, Susan E., Johnson, Dale E., Rowlinson, Scott W., Georgiou, George, Lee, Brendan H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007608/
https://ncbi.nlm.nih.gov/pubmed/26358771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv352
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