Recombinant Human Arginase Toxicity in Mice Is Reduced by Citrulline Supplementation

Human recombinant arginase I cobalt coupled to polyethylene glycol 5000 (HuArg I [Co]-PEG5000) achieved potent in vitro depletion of arginine from tissue culture medium and cytotoxicity to many cancer cell lines. The recombinant enzyme also produced tumor growth inhibition of hepatocellular carcinom...

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Detalhes bibliográficos
Main Authors: Mauldin, Jeremy P, Zeinali, Ideen, Kleypas, Keri, Woo, Jung Hee, Blackwood, Rebecca S, Jo, Chan-Hee, Stone, Everett M, Georgiou, George, Frankel, Arthur E
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press Inc. 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3281408/
https://ncbi.nlm.nih.gov/pubmed/22348173
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