SCHEMA Designed Variants of Human Arginase I & II Reveal Sequence Elements Important to Stability and Catalysis

Arginases catalyze the divalent cation-dependent hydrolysis of L-arginine to urea and L-ornithine. There is significant interest in using arginase as a therapeutic anti-neogenic agent against L-arginine auxotrophic tumors and in enzyme replacement therapy for treating hyperargininemia. Both therapeu...

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Main Authors: Romero, Philip A., Stone, Everett, Lamb, Candice, Chantranupong, Lynne, Krause, Andreas, Miklos, Alex, Hughes, Randall A., Fechtel, Blake, Ellington, Andrew D., Arnold, Frances H., Georgiou, George
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3378063/
https://ncbi.nlm.nih.gov/pubmed/22737599
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/sb300014t
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