Altered nuclear co-factor switching in retinoic resistant variants of the PML-RARα oncoprotein of acute promyelocytic leukemia

Acute Promyelocytic Leukemia (APL) results from a reciprocal translocation that fuses the gene for the PML tumor suppressor to that encoding the retinoic acid receptor alpha (RARα). The resulting PML-RARα oncogene product interferes with multiple regulatory pathways associated with myeloid different...

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Bibliographic Details
Main Authors: Farris, Mindy, Lague, Astrid, Manuelyan, Zara, Statnekov, Jacob, Francklyn, Christopher
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3294029/
https://ncbi.nlm.nih.gov/pubmed/22228505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24010
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