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Methylation of Wnt7a Is Modulated by DNMT1 and Cigarette Smoke Condensate in Non-Small Cell Lung Cancer

Wnt7a is known to be a tumor suppressor that is lost in NSCLC, but no mechanism of loss has been established. Methylation of promoter regions has been established as a common mechanism of loss of tumor suppressor expression in NSCLC. We previously demonstrated that loss of Wnt7a in non-transformed l...

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Detalhes bibliográficos
Main Authors: Tennis, Meredith A., VanScoyk, Michelle M., Wilson, Lora A., Kelley, Nicole, Winn, Robert A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293913/
https://ncbi.nlm.nih.gov/pubmed/22403725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032921
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