Down-regulation of BLIMP1α by the EBV oncogene, LMP-1, disrupts the plasma cell differentiation program and prevents viral replication in B cells: implications for the pathogenesis of EBV-associated B-cell lymphomas

An important pathogenic event in Epstein-Barr virus (EBV)-associated lymphomas is the suppression of virus replication, which would otherwise lead to cell death. Because virus replication in B cells is intimately linked to their differentiation toward plasma cells, we asked whether the physiologic s...

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Detalhes bibliográficos
Main Authors: Vrzalikova, Katerina, Vockerodt, Martina, Leonard, Sarah, Bell, Andrew, Wei, Wenbin, Schrader, Alexandra, Wright, Kenneth L., Kube, Dieter, Rowe, Martin, Woodman, Ciaran B., Murray, Paul G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293751/
https://ncbi.nlm.nih.gov/pubmed/21411757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-09-307710
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