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Hypomethylation and Over-Expression of the Beta Isoform of BLIMP1 is Induced by Epstein-Barr Virus Infection of B Cells; Potential Implications for the Pathogenesis of EBV-Associated Lymphomas
B-lymphocyte-induced maturation protein 1 (BLIMP1) exists as two major isoforms, α and β, which arise from alternate promoters. Inactivation of the full length BLIMP1α isoform is thought to contribute to B cell lymphomagenesis by blocking post-germinal centre (GC) B cell differentiation. In contrast...
Guardat en:
Publicat a: | Pathogens |
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Autors principals: | , , , , , , , , , |
Format: | Artigo |
Idioma: | Inglês |
Publicat: |
MDPI
2012
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Matèries: | |
Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4235687/ https://ncbi.nlm.nih.gov/pubmed/25436766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pathogens1020083 |
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