Influence of single nucleotide polymorphisms in factor VIII and von Willebrand factor genes on plasma factor VIII activity: the ARIC Study

Factor VIII (FVIII) functions as a cofactor for factor IXa in the contact coagulation pathway and circulates in a protective complex with von Willebrand factor (VWF). Plasma FVIII activity is strongly influenced by environmental and genetic factors through VWF-dependent and -independent mechanisms....

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Autors principals: Campos, Marco, Buchanan, Ashley, Yu, Fuli, Barbalic, Maja, Xiao, Yang, Chambless, Lloyd E., Wu, Kenneth K., Folsom, Aaron R., Boerwinkle, Eric, Dong, Jing-fei
Format: Artigo
Idioma:Inglês
Publicat: American Society of Hematology 2012
Matèries:
Thrombosis and Hemostasis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293647/
https://ncbi.nlm.nih.gov/pubmed/22219226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-10-383661
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