Self-complementary AAVs Induce More Potent Transgene Product-specific Immune Responses Compared to a Single-stranded Genome

Using a mouse model we show that self-complementary (sc) adeno-associated virus (AAV) vectors pseudotyped with capsids of serotypes 2, 7 or 8 induce more potent transgene product-specific CD8(+) T cell and antibody responses compared to corresponding single-stranded (ss)AAV vectors. These data sugge...

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Detalhes bibliográficos
Main Authors: Wu, TeLang, Töpfer, Katrin, Lin, Shih-Wen, Li, Hua, Bian, Ang, Zhou, Xiang Y, High, Katherine A, Ertl, Hildegund CJ
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293612/
https://ncbi.nlm.nih.gov/pubmed/22186792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mt.2011.280
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