Serine Hydroxymethyltransferase Anchors de Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

The de novo thymidylate biosynthetic pathway in mammalian cells translocates to the nucleus for DNA replication and repair and consists of the enzymes serine hydroxymethyltransferase 1 and 2α (SHMT1 and SHMT2α), thymidylate synthase, and dihydrofolate reductase. In this study, we demonstrate that th...

Full description

Saved in:
Bibliographic Details
Main Authors: Anderson, Donald D., Woeller, Collynn F., Chiang, En-Pei, Shane, Barry, Stover, Patrick J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2012
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293584/
https://ncbi.nlm.nih.gov/pubmed/22235121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333120
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items