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Serine Hydroxymethyltransferase Anchors de Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

The de novo thymidylate biosynthetic pathway in mammalian cells translocates to the nucleus for DNA replication and repair and consists of the enzymes serine hydroxymethyltransferase 1 and 2α (SHMT1 and SHMT2α), thymidylate synthase, and dihydrofolate reductase. In this study, we demonstrate that th...

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Detalhes bibliográficos
Main Authors: Anderson, Donald D., Woeller, Collynn F., Chiang, En-Pei, Shane, Barry, Stover, Patrick J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293584/
https://ncbi.nlm.nih.gov/pubmed/22235121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333120
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