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Serine Hydroxymethyltransferase Anchors de Novo Thymidylate Synthesis Pathway to Nuclear Lamina for DNA Synthesis

The de novo thymidylate biosynthetic pathway in mammalian cells translocates to the nucleus for DNA replication and repair and consists of the enzymes serine hydroxymethyltransferase 1 and 2α (SHMT1 and SHMT2α), thymidylate synthase, and dihydrofolate reductase. In this study, we demonstrate that th...

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書誌詳細
主要な著者: Anderson, Donald D., Woeller, Collynn F., Chiang, En-Pei, Shane, Barry, Stover, Patrick J.
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Biochemistry and Molecular Biology 2012
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293584/
https://ncbi.nlm.nih.gov/pubmed/22235121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.333120
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