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Characterization of BRCA1 Protein Targeting, Dynamics, and Function at the Centrosome: A ROLE FOR THE NUCLEAR EXPORT SIGNAL, CRM1, AND AURORA A KINASE
BRCA1 is a DNA damage response protein and functions in the nucleus to stimulate DNA repair and at the centrosome to inhibit centrosome overduplication in response to DNA damage. The loss or mutation of BRCA1 causes centrosome amplification and abnormal mitotic spindle assembly in breast cancer cell...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3293534/ https://ncbi.nlm.nih.gov/pubmed/22262852 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.327296 |
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