Synthesis of New 6-{[ω-(Dialkylamino(heterocyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones and Evaluation of their Anticancer and Antimicrobial Activities

Several novel 6-thio-3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazoline-based compounds containing an ω-(dialkylamino(heterocyclyl)]alkyl fragment were synthesized to examine their anticancer activity. Some of the 6-{[ω-(hetero-cyclyl)alkyl]thio}-3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones (3.1–3.10...

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Detalhes bibliográficos
Main Authors: Berest, Galina G., Voskoboynik, Olexiy Y., Kovalenko, Sergiy I., Nosulenko, Inna S., Antypenko, Lyudmyla M., Antypenko, Olexii M., Shvets, Volodymyr M., Katsev, Andriy M.
Formato: Artigo
Idioma:Inglês
Publicado em: Österreichische Apotheker-Verlagsgesellschaft 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293349/
https://ncbi.nlm.nih.gov/pubmed/22396903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3797/scipharm.1111-15
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