Desing, synthesis and anti-inflammatory activity of dirivatives 10-R-3-aryl-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones of spiro-fused cyclic frameworks

Present work is devoted to the purposeful search of novel promising anti-inflammatory agents among the insufficiently known 3'-R-10'-R1-spiro[hetaryl-3(4),6'-[1,2,4]triazino[2,3-c]quinazolin]-2'(7'H)-ones. The virtual combinatorial library of previously unknown spiro-condens...

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Hlavní autoři: Oleksandra Kolomoets, Oleksii Voskoboynik, Oleksii Antypenko, Galyna Berest, Inna Nosulenko, Vitaliy Palchikov, Olexandr Karpenko, Sergiy Kovalenko
Médium: Artigo
Jazyk:Inglês
Vydáno: Slovenian Chemical Society 2017-12-01
Edice:Acta Chimica Slovenica
Témata:
6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin-2-ones
spiro-fused cycle
synthesis
molecular docking
anti-inflammatory activity
On-line přístup:https://journals.matheo.si/index.php/ACSi/article/view/3575
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