Substituted 2-[(2-Oxo-2H-[1,2,4]triazino [2,3-c]quinazolin-6-yl)thio]acetamides with Thiazole and Thiadiazole Fragments: Synthesis, Physicochemical Properties, Cytotoxicity, and Anticancer Activity

The series of novel N-R-2-[(3-R-2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thio]acetamides with thiazole and thiadiazole fragments in a molecule were obtained by alkylation of potassium salts 1.1–1.4 by N-hetaryl-2-chloroacetamides and by aminolysis of activated acids 2.1–2.4 with N,N’-carbonyld...

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Main Authors: Kovalenko, Sergey I., Nosulenko, Inna S., Voskoboynik, Alexey Yu., Berest, Galina G., Antypenko, Lyudmyla N., Antypenko, Alexey N., Katsev, Andrey M.
Formato: Artigo
Idioma:Inglês
Publicado em: Österreichische Apotheker-Verlagsgesellschaft 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528059/
https://ncbi.nlm.nih.gov/pubmed/23264935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3797/scipharm.1208-07
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