Exogenous seeding of cerebral β-amyloid deposition in βAPP-transgenic rats

Deposition of the Aβ peptide in senile plaques and cerebral Aβ angiopathy can be stimulated in Aβ-precursor protein-transgenic mice by the intracerebral injection of dilute brain extracts containing aggregated Aβ seeds. Growing evidence implicates a prion-like mechanism of corruptive protein templat...

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Main Authors: Rosen, Rebecca F., Fritz, Jason J., Dooyema, Jeromy, Cintron, Amarallys F., Hamaguchi, Tsuyoshi, Lah, James J., LeVine, Harry, Jucker, Mathias, Walker, Lary C.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3293176/
https://ncbi.nlm.nih.gov/pubmed/22017494
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1471-4159.2011.07551.x
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