Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice

Calorie restriction results in leanness, which is linked to metabolic conditions that favor longevity. We show here that deficiency of the triglyceride synthesis enzyme acyl CoA:diacylglycerol acyltransferase 1 (DGAT1), which promotes leanness, also extends longevity without limiting food intake. Fe...

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Detalhes bibliográficos
Main Authors: Streeper, Ryan S., Grueter, Carrie A., Salomonis, Nathan, Cases, Sylvaine, Levin, Malin C., Koliwad, Suneil K., Zhou, Ping, Hirschey, Matthew D., Verdin, Eric, Farese, Robert V.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2012
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292902/
https://ncbi.nlm.nih.gov/pubmed/22291164
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