DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

Diet-induced obesity (DIO) leads to inflammatory activation of macrophages in white adipose tissue (WAT) and subsequently to insulin resistance. PPARγ agonists are antidiabetic agents known to suppress inflammatory macrophage activation and to induce expression of the triacylglycerol (TG) synthesis...

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Detalhes bibliográficos
Main Authors: Koliwad, Suneil K., Streeper, Ryan S., Monetti, Mara, Cornelissen, Ivo, Chan, Liana, Terayama, Koji, Naylor, Stephen, Rao, Meghana, Hubbard, Brian, Farese, Robert V.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827941/
https://ncbi.nlm.nih.gov/pubmed/20124729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36066
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