DGAT1-dependent triacylglycerol storage by macrophages protects mice from diet-induced insulin resistance and inflammation

Diet-induced obesity (DIO) leads to inflammatory activation of macrophages in white adipose tissue (WAT) and subsequently to insulin resistance. PPARγ agonists are antidiabetic agents known to suppress inflammatory macrophage activation and to induce expression of the triacylglycerol (TG) synthesis...

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Hauptverfasser: Koliwad, Suneil K., Streeper, Ryan S., Monetti, Mara, Cornelissen, Ivo, Chan, Liana, Terayama, Koji, Naylor, Stephen, Rao, Meghana, Hubbard, Brian, Farese, Robert V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2010
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2827941/
https://ncbi.nlm.nih.gov/pubmed/20124729
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36066
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