A combination of a ribonucleotide reductase inhibitor and histone deacetylase inhibitors downregulates EGFR and triggers BIM-dependent apoptosis in head and neck cancer

Head and neck squamous cell carcinomas (HNSCCs) are the sixth most common malignant neoplasm and more than 50% of patients succumb to this disease. HNSCCs are characterized by therapy resistance, which relies on the overexpression of anti-apoptotic proteins and on the aberrant regulation of the epid...

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Autori principali: Stauber, Roland H., Knauer, Shirley K., Habtemichael, Negusse, Bier, Carolin, Unruhe, Britta, Weisheit, Simona, Spange, Stephanie, Nonnenmacher, Frank, Fetz, Verena, Ginter, Torsten, Reichardt, Sigrid, Liebmann, Claus, Schneider, Günter, Krämer, Oliver H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Impact Journals LLC 2011
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292890/
https://ncbi.nlm.nih.gov/pubmed/22289787
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