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Pharmacogenetic Warfarin Dose Refinements Remain Significantly Influenced by Genetic Factors after One Week of Therapy

INTRODUCTION: By guiding initial warfarin dose, pharmacogenetic (PGx) algorithms may improve the safety of warfarin initiation. However, once INR response is known, the contribution of PGx to dose refinements is uncertain. This study sought to develop and validate clinical and PGx dosing algorithms...

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Main Authors: Horne, Benjamin D., Lenzini, Petra A., Wadelius, Mia, Jorgensen, Andrea L., Kimmel, Stephen E., Ridker, Paul M., Eriksson, Niclas, Anderson, Jeffrey L., Pirmohamed, Munir, Limdi, Nita A., Pendleton, Robert C., McMillin, Gwendolyn A., Burmester, James K., Kurnik, Daniel, Stein, C. Michael, Caldwell, Michael D., Eby, Charles S., Rane, Anders, Lindh, Jonatan D., Shin, Jae-Gook, Kim, Ho-Sook, Angchaisuksiri, Pantep, Glynn, Robert J., Kronquist, Kathryn E., Carlquist, John F., Grice, Gloria R., Barrack, Robert L., Li, Juan, Gage, Brian F.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292349/
https://ncbi.nlm.nih.gov/pubmed/22186998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1160/TH11-06-0388
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