Integration of genetic, clinical, and INR data to refine warfarin dosing

BACKGROUND: Well characterized genes affecting warfarin metabolism (CYP2C9) and sensitivity (VKORC1) explain one-third of the variability in therapeutic dose before the International Normalized Ratio (INR) is measured. METHODS: To determine genotypic relevance after INR becomes available, we derived...

Celý popis

Uloženo v:
Podrobná bibliografie
Hlavní autoři: Lenzini, P., Wadelius, M., Kimmel, S., Anderson, J.L., Jorgensen, A.L, Pirmohamed, M., Caldwell, M.D., Limdi, N., Burmester, J.K., Dowd, M.B., Angchaisuksiri, P., Bass, A.R., Chen, J., Eriksson, N., Rane, A., Lindh, J.D., Carlquist, J.F., Horne, B.D., Grice, G., Milligan, P.E., Eby, C., Shin, J., Kim, H., Kurnik, D., Stein, C.M., McMillin, G., Pendleton, R.C., Berg, R.L., Deloukas, P., Gage, B.F.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858245/
https://ncbi.nlm.nih.gov/pubmed/20375999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/clpt.2010.13
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky