Increased GABAergic Output in the Ventromedial Hypothalamus Contributes to Impaired Hypoglycemic Counterregulation in Diabetic Rats

OBJECTIVE: Impaired glucose counterregulation during hypoglycemia is well documented in patients with type 1 diabetes; however, the molecular mechanisms underlying this defect remain uncertain. We reported that the inhibitory neurotransmitter γ-aminobutyric acid (GABA), in a crucial glucose-sensing...

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Главные авторы: Chan, Owen, Paranjape, Sachin, Czyzyk, Daniel, Horblitt, Adam, Zhu, Wanling, Ding, Yuyan, Fan, Xiaoning, Seashore, Margretta, Sherwin, Robert
Формат: Artigo
Язык:Inglês
Опубликовано: American Diabetes Association 2011
Предметы:
Complications
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292334/
https://ncbi.nlm.nih.gov/pubmed/21411513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db10-1579
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