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Computational Studies of Difference in Binding Modes of Peptide and Non-Peptide Inhibitors to MDM2/MDMX Based on Molecular Dynamics Simulations

Inhibition of p53-MDM2/MDMX interaction is considered to be a promising strategy for anticancer drug design to activate wild-type p53 in tumors. We carry out molecular dynamics (MD) simulations to study the binding mechanisms of peptide and non-peptide inhibitors to MDM2/MDMX. The rank of binding fr...

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Autors principals: Chen, Jianzhong, Zhang, Dinglin, Zhang, Yuxin, Li, Guohui
Format: Artigo
Idioma:Inglês
Publicat: Molecular Diversity Preservation International (MDPI) 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3292015/
https://ncbi.nlm.nih.gov/pubmed/22408446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms13022176
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