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Haploinsufficiency of the genes encoding the tumor suppressor Pten predisposes zebrafish to hemangiosarcoma
PTEN is an essential tumor suppressor that antagonizes Akt/PKB signaling. The zebrafish genome encodes two Pten genes, ptena and ptenb. Here, we report that zebrafish mutants that retain a single wild-type copy of ptena or ptenb (ptena(+/−)ptenb(−/−) or ptena(−/−)ptenb(+/−)) are viable and fertile....
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
The Company of Biologists Limited
2012
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3291645/ https://ncbi.nlm.nih.gov/pubmed/22071262 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.008326 |
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