Model for long QT syndrome type 2 using human iPS cells demonstrates arrhythmogenic characteristics in cell culture

Long QT syndrome (LQTS) is caused by functional alterations in cardiac ion channels and is associated with prolonged cardiac repolarization time and increased risk of ventricular arrhythmias. Inherited type 2 LQTS (LQT2) and drug-induced LQTS both result from altered function of the hERG channel. We...

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Hlavní autoři: Lahti, Anna L., Kujala, Ville J., Chapman, Hugh, Koivisto, Ari-Pekka, Pekkanen-Mattila, Mari, Kerkelä, Erja, Hyttinen, Jari, Kontula, Kimmo, Swan, Heikki, Conklin, Bruce R., Yamanaka, Shinya, Silvennoinen, Olli, Aalto-Setälä, Katriina
Médium: Artigo
Jazyk:Inglês
Vydáno: The Company of Biologists Limited 2012
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291643/
https://ncbi.nlm.nih.gov/pubmed/22052944
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.008409
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