Distinct electrophysiological and mechanical beating phenotypes of long QT syndrome type 1-specific cardiomyocytes carrying different mutations

BACKGROUND: Long QT syndrome (LQTS) is associated with increased risk of ventricular arrhythmias and cardiac arrest. LQTS type 1 (LQT1), the most prevalent subtype of LQTS, is caused by defects of slow delayed rectifier potassium current (I(Ks)) that lead to abnormal cardiac repolarization. Here we...

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Detalhes bibliográficos
Publicado no:Int J Cardiol Heart Vasc
Main Authors: Kiviaho, Anna L., Ahola, Antti, Larsson, Kim, Penttinen, Kirsi, Swan, Heikki, Pekkanen-Mattila, Mari, Venäläinen, Henna, Paavola, Kiti, Hyttinen, Jari, Aalto-Setälä, Katriina
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5497295/
https://ncbi.nlm.nih.gov/pubmed/28785673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ijcha.2015.04.008
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