Uptake Mechanism of ApoE-Modified Nanoparticles on Brain Capillary Endothelial Cells as a Blood-Brain Barrier Model

BACKGROUND: The blood-brain barrier (BBB) represents an insurmountable obstacle for most drugs thus obstructing an effective treatment of many brain diseases. One solution for overcoming this barrier is a transport by binding of these drugs to surface-modified nanoparticles. Especially apolipoprotei...

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Autores principales: Wagner, Sylvia, Zensi, Anja, Wien, Sascha L., Tschickardt, Sabrina E., Maier, Wladislaw, Vogel, Tikva, Worek, Franz, Pietrzik, Claus U., Kreuter, Jörg, von Briesen, Hagen
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2012
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291552/
https://ncbi.nlm.nih.gov/pubmed/22396775
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032568
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