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Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged
We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility index quantify differences within backbone flexibilit...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3291535/ https://ncbi.nlm.nih.gov/pubmed/22396637 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002409 |
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