Changes in Lysozyme Flexibility upon Mutation Are Frequent, Large and Long-Ranged

We investigate changes in human c-type lysozyme flexibility upon mutation via a Distance Constraint Model, which gives a statistical mechanical treatment of network rigidity. Specifically, two dynamical metrics are tracked. Changes in flexibility index quantify differences within backbone flexibilit...

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Main Authors: Verma, Deeptak, Jacobs, Donald J., Livesay, Dennis R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291535/
https://ncbi.nlm.nih.gov/pubmed/22396637
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1002409
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