Regulation of β-adrenergic control of heart rate by GTP-cyclohydrolase 1 (GCH1) and tetrahydrobiopterin

AIMS: Clinical markers of cardiac autonomic function, such as heart rate and response to exercise, are important predictors of cardiovascular risk. Tetrahydrobiopterin (BH4) is a required cofactor for enzymes with roles in cardiac autonomic function, including tyrosine hydroxylase and nitric oxide s...

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Autori principali: Adlam, David, Herring, Neil, Douglas, Gillian, De Bono, Joseph P., Li, Dan, Danson, Edward J., Tatham, Amy, Lu, Cheih-Ju, Jennings, Katie A., Cragg, Stephanie J., Casadei, Barbara, Paterson, David J., Channon, Keith M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2012
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Original Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3291091/
https://ncbi.nlm.nih.gov/pubmed/22241166
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvs005
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