Tissue type is a major modifier of the 5-hydroxymethylcytosine content of human genes

The discovery of substantial amounts of 5-hydroxymethylcytosine (5hmC), formed by the oxidation of 5-methylcytosine (5mC), in various mouse tissues and human embryonic stem (ES) cells has necessitated a reevaluation of our knowledge of 5mC/5hmC patterns and functions in mammalian cells. Here, we inv...

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Autors principals: Nestor, Colm E., Ottaviano, Raffaele, Reddington, James, Sproul, Duncan, Reinhardt, Diana, Dunican, Donncha, Katz, Elad, Dixon, J. Michael, Harrison, David J., Meehan, Richard R.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2012
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290782/
https://ncbi.nlm.nih.gov/pubmed/22106369
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.126417.111
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