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Perturbation of the Hematopoietic System during Embryonic Liver Development Due to Disruption of Polyubiquitin Gene Ubc in Mice

Disruption of the polyubiquitin gene Ubc leads to a defect in fetal liver development, which can be partially rescued by increasing the amount of ubiquitin. However, it is still not known why Ubc is required for fetal liver development and the nature of the defective cell types responsible for embry...

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Main Authors: Ryu, Kwon-Yul, Park, Hyejin, Rossi, Derrick J., Weissman, Irving L., Kopito, Ron R.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290595/
https://ncbi.nlm.nih.gov/pubmed/22393459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032956
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