Sustained activation of PPARα by endogenous ligands increases hepatic fatty acid oxidation and prevents obesity in ob/ob mice

Obesity, a major health concern, results from an imbalance between energy intake and expenditure. Leptin-deficient ob/ob mice are paradigmatic of obesity, resulting from excess energy intake and storage. Mice lacking acyl-CoA oxidase 1 (Acox1), the first enzyme of the peroxisomal fatty acid β-oxidat...

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Autores principales: Huang, Jiansheng, Jia, Yuzhi, Fu, Tao, Viswakarma, Navin, Bai, Liang, Rao, M. Sambasiva, Zhu, Yijun, Borensztajn, Jayme, Reddy, Janardan K.
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2012
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290446/
https://ncbi.nlm.nih.gov/pubmed/22009939
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-194019
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