Progressive Endoplasmic Reticulum Stress Contributes to Hepatocarcinogenesis in Fatty Acyl-CoA Oxidase 1–Deficient Mice

Fatty acyl-coenzyme A oxidase 1 (ACOX1) knockout (ACOX1(−/−)) mice manifest hepatic metabolic derangements that lead to the development of steatohepatitis, hepatocellular regeneration, spontaneous peroxisome proliferation, and hepatocellular carcinomas. Deficiency of ACOX1 results in unmetabolized s...

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Detalhes bibliográficos
Main Authors: Huang, Jiansheng, Viswakarma, Navin, Yu, Songtao, Jia, Yuzhi, Bai, Liang, Vluggens, Aurore, Cherkaoui-Malki, Mustapha, Khan, Mushfiquddin, Singh, Inderjit, Yang, Gongshe, Rao, M. Sambasiva, Borensztajn, Jayme, Reddy, Janardan K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157234/
https://ncbi.nlm.nih.gov/pubmed/21801867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.04.030
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