Structural aspects of M(3) muscarinic acetylcholine receptor dimer formation and activation

To explore the structural mechanisms underlying the assembly and activation of family A GPCR dimers, we used the rat M(3) muscarinic acetylcholine receptor (M3R) as a model system. Studies with Cys-substituted mutant M3Rs expressed in COS-7 cells led to the identification of several mutant M3Rs that...

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Autores principales: Hu, Jianxin, Thor, Doreen, Zhou, Yaru, Liu, Tong, Wang, Yan, McMillin, Sara M., Mistry, Rajendra, Challiss, R. A. John, Costanzi, Stefano, Wess, Jürgen
Formato: Artigo
Lenguaje:Inglês
Publicado: Federation of American Societies for Experimental Biology 2012
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3290441/
https://ncbi.nlm.nih.gov/pubmed/22031716
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-191510
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