טוען...
Determinants of Reactivity and Selectivity in Soluble Epoxide Hydrolase from Quantum Mechanics/Molecular Mechanics Modeling
[Image: see text] Soluble epoxide hydrolase (sEH) is an enzyme involved in drug metabolism that catalyzes the hydrolysis of epoxides to form their corresponding diols. sEH has a broad substrate range and shows high regio- and enantioselectivity for nucleophilic ring opening by Asp333. Epoxide hydrol...
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| Main Authors: | , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
American Chemical
Society
2012
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| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3290109/ https://ncbi.nlm.nih.gov/pubmed/22280021 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201722j |
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