Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains

Epigenetic mechanisms regulating leukemia stem cells (LSCs) are an attractive target for therapy of blood cancers. Here, we report that conditional knockout of the DNA methyltransferase Dnmt1 blocked development of leukemia, and haploinsufficiency of Dnmt1 was sufficient to delay progression of leuk...

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Détails bibliographiques
Auteurs principaux: Trowbridge, Jennifer J., Sinha, Amit U., Zhu, Nan, Li, Mingjie, Armstrong, Scott A., Orkin, Stuart H.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2012
Sujets:
Research Communication
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289882/
https://ncbi.nlm.nih.gov/pubmed/22345515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.184341.111
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