Human aging-associated DNA hypermethylation occurs preferentially at bivalent chromatin domains

There is a growing realization that some aging-associated phenotypes/diseases have an epigenetic basis. Here, we report the first genome-scale study of epigenomic dynamics during normal human aging. We identify aging-associated differentially methylated regions (aDMRs) in whole blood in a discovery...

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Autors principals: Rakyan, Vardhman K., Down, Thomas A., Maslau, Siarhei, Andrew, Toby, Yang, Tsun-Po, Beyan, Huriya, Whittaker, Pamela, McCann, Owen T., Finer, Sarah, Valdes, Ana M., Leslie, R. David, Deloukas, Panogiotis, Spector, Timothy D.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2010
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2847746/
https://ncbi.nlm.nih.gov/pubmed/20219945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.103101.109
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