Adipocyte-Specific Protein Tyrosine Phosphatase 1B Deletion Increases Lipogenesis, Adipocyte Cell Size and Is a Minor Regulator of Glucose Homeostasis

Protein tyrosine phosphatase 1B (PTP1B), a key negative regulator of leptin and insulin signaling, is positively correlated with adiposity and contributes to insulin resistance. Global PTP1B deletion improves diet-induced obesity and glucose homeostasis via enhanced leptin signaling in the brain and...

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Detalhes bibliográficos
Main Authors: Owen, Carl, Czopek, Alicja, Agouni, Abdelali, Grant, Louise, Judson, Robert, Lees, Emma K., Mcilroy, George D., Göransson, Olga, Welch, Andy, Bence, Kendra K., Kahn, Barbara B., Neel, Benjamin G., Mody, Nimesh, Delibegović, Mirela
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289674/
https://ncbi.nlm.nih.gov/pubmed/22389718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032700
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