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Structural Stability of Human Protein Tyrosine Phosphatase ρ Catalytic Domain: Effect of Point Mutations

Protein tyrosine phosphatase ρ (PTPρ) belongs to the classical receptor type IIB family of protein tyrosine phosphatase, the most frequently mutated tyrosine phosphatase in human cancer. There are evidences to suggest that PTPρ may act as a tumor suppressor gene and dysregulation of Tyr phosphorylat...

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Autors principals: Pasquo, Alessandra, Consalvi, Valerio, Knapp, Stefan, Alfano, Ivan, Ardini, Matteo, Stefanini, Simonetta, Chiaraluce, Roberta
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289658/
https://ncbi.nlm.nih.gov/pubmed/22389709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032555
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