A Catalytic Mechanism for Cysteine N-Terminal Nucleophile Hydrolases, as Revealed by Free Energy Simulations

The N-terminal nucleophile (Ntn) hydrolases are a superfamily of enzymes specialized in the hydrolytic cleavage of amide bonds. Even though several members of this family are emerging as innovative drug targets for cancer, inflammation, and pain, the processes through which they catalyze amide hydro...

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Detaylı Bibliyografya
Asıl Yazarlar: Lodola, Alessio, Branduardi, Davide, De Vivo, Marco, Capoferri, Luigi, Mor, Marco, Piomelli, Daniele, Cavalli, Andrea
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2012
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289653/
https://ncbi.nlm.nih.gov/pubmed/22389698
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0032397
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