Distinctive immunoregulatory effects of adenosine on T cells of older humans

A role for adenosine in immunosenescence was investigated in T cells from older (≥65 yr) and younger (24–45 yr) healthy humans. Adenosine concentrations in cultures of activated T cells were significantly higher (P<0.0001) for older (145±47 nM, mean±sd) than younger (58±5.5 nM) subjects. Expressi...

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Autors principals: Hesdorffer, Charles S., Malchinkhuu, Enkhzol, Biragyn, Arya, Mabrouk, Omar S., Kennedy, Robert T., Madara, Karen, Taub, Dennis D., Longo, Dan L., Schwartz, Janice B., Ferrucci, Luigi, Goetzl, Edward J.
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2012
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289505/
https://ncbi.nlm.nih.gov/pubmed/22121051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.11-197046
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