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Synaptic release and extracellular actions of Zn(2+) limit propagation of spreading depression and related events in vitro and in vivo

Cortical spreading depression (CSD) is a consequence of a slowly propagating wave of neuronal and glial depolarization (spreading depolarization; SD). Massive release of glutamate contributes to SD propagation, and it was recently shown that Zn(2+) is also released from synaptic vesicles during SD....

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Detalhes bibliográficos
Main Authors: Aiba, Isamu, Carlson, Andrew P., Sheline, Christian T., Shuttleworth, C. William
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289481/
https://ncbi.nlm.nih.gov/pubmed/22131381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00453.2011
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