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Antibody directs properdin-dependent activation of the complement alternative pathway in a mouse model of abdominal aortic aneurysm

Abdominal aortic aneurysm (AAA) is a complex inflammatory vascular disease. There are currently limited treatment options for AAA when surgery is inapplicable. Therefore, insights into molecular mechanisms underlying AAA pathogenesis may reveal therapeutic targets that could be manipulated pharmacol...

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Autors principals: Zhou, Hui-fang, Yan, Huimin, Stover, Cordula M., Fernandez, Tamara Montes, Rodriguez de Cordoba, Santiago, Song, Wen-Chao, Wu, Xiaobo, Thompson, Robert W., Schwaeble, Wilhelm J., Atkinson, John P., Hourcade, Dennis E., Pham, Christine T. N.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289386/
https://ncbi.nlm.nih.gov/pubmed/22308431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1119000109
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