Functional redundancy between repair factor XLF and damage response mediator 53BP1 in V(D)J recombination and DNA repair

The classical nonhomologous DNA end-joining (C-NHEJ) double-strand break (DSB) repair pathway in mammalian cells maintains genome stability and is required for V(D)J recombination and lymphocyte development. Mutations in the XLF C-NHEJ factor or ataxia telangiectasia-mutated (ATM) DSB response prote...

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Autors principals: Oksenych, Valentyn, Alt, Frederick W., Kumar, Vipul, Schwer, Bjoern, Wesemann, Duane R., Hansen, Erica, Patel, Harin, Su, Arthur, Guo, Chunguang
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2012
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289340/
https://ncbi.nlm.nih.gov/pubmed/22308489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1121458109
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