Quantitative modeling of the terminal differentiation of B cells and mechanisms of lymphomagenesis

Mature B-cell exit from germinal centers is controlled by a transcriptional regulatory module that integrates antigen and T-cell signals and, ultimately, leads to terminal differentiation into memory B cells or plasma cells. Despite a compact structure, the module dynamics are highly complex because...

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Библиографические подробности
Главные авторы: Martínez, María Rodríguez, Corradin, Alberto, Klein, Ulf, Álvarez, Mariano Javier, Toffolo, Gianna M., di Camillo, Barbara, Califano, Andrea, Stolovitzky, Gustavo A.
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2012
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289327/
https://ncbi.nlm.nih.gov/pubmed/22308355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113019109
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