Tcl1 protein functions as an inhibitor of de novo DNA methylation in B-cell chronic lymphocytic leukemia (CLL)

B-cell chronic lymphocytic leukemia (CLL) is the most common human leukemia. Deregulation of the T-cell leukemia/lymphoma 1 oncogene (TCL1) in mouse B cells causes a CD5(+) leukemia similar to aggressive human CLL. To examine the mechanisms by which Tcl1 protein exerts its oncogenic activity in B ce...

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Huvudupphovsmän: Palamarchuk, Alexey, Yan, Pearlly S., Zanesi, Nicola, Wang, Linan, Rodrigues, Benjamin, Murphy, Mark, Balatti, Veronica, Bottoni, Arianna, Nazaryan, Natalya, Alder, Hansjuerg, Rassenti, Laura, Kipps, Thomas J., Freitas, Michael, Croce, Carlo M., Pekarsky, Yuri
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2012
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3289317/
https://ncbi.nlm.nih.gov/pubmed/22308499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1200003109
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